Ye Cheng - Biomarker Imaging Approaches - Bioimaging Advances Award

Xuanwu Hospital Capital Medical University - China

AUTHOR PROFILE  

     SCOPUS

🎓 EARLY ACADEMIC PURSUITS

YE CHENG’s academic foundation is rooted in rigorous training, having honed his expertise at Harvard Medical School’s prestigious institutions, BWH and MGH. These formative years equipped him with advanced skills in neurosurgery and research. His commitment to neuroscience and targeted therapy began early, combining theoretical learning with practical mastery. This powerful combination laid the groundwork for his groundbreaking work in neuro-oncology. Now an Associate Professor, he uses his deep understanding of cortical structures and tumor biology to fuel a research career that bridges academia and medicine, setting him on a path to international scholarly recognition.

🧠 PROFESSIONAL ENDEAVORS

Currently serving as an Attending at Xuanwu Hospital, Capital Medical University, YE CHENG demonstrates an exceptional ability to integrate research with clinical application. His daily neurosurgical practice is informed by years of data-driven inquiry and innovative problem-solving. He has published extensively—over 20 articles in SCI-indexed journals—with work appearing in BMC Medicine and Cancer Letters. Cheng’s practical experience enhances his research authenticity, while his scientific expertise strengthens his role in complex surgeries. Through this synergy, he’s not just treating disease—he’s redefining the boundaries of what neurosurgeons can achieve in research-intensive clinical environments.

🔍 CONTRIBUTIONS AND RESEARCH FOCUS

YE CHENG’s research centers on the pathogenesis and treatment of central nervous system tumors. His pivotal discovery revealed that gliomas from different cortical regions carry varied prognoses due to underlying genetic differences. Published in Genes & Diseases, his findings link higher-order cortical development to tumor metabolism via ¹⁸F-FET PET imaging. This fusion of neuroevolution and oncology provides fresh insight into tumor behavior and paves the way for personalized treatments. Cheng's work highlights the significance of brain architecture in cancer development, laying a strong foundation for future research on neuro-tumor dynamics.

🧬 INNOVATION AND SCIENTIFIC ADVANCEMENT

YE CHENG’s research innovations extend beyond theories into impactful tools and technologies. He holds two authorized national invention patents, both rooted in his drive to improve diagnostic and surgical techniques. His interdisciplinary expertise bridges molecular imaging, neuroscience, and neurosurgery. By leveraging advanced radiopharmaceuticals, he introduced ¹⁸F-FET PET into tumor diagnostics, redefining how clinicians approach gliomas. This method helps identify tumor metabolism patterns and aligns treatment plans with tumor origin. Cheng’s integration of evolution, imaging, and genetics positions him at the forefront of translational neuro-oncology, pushing science toward more targeted and intelligent cancer care.

🏅 ACCOLADES AND RECOGNITION

YE CHENG’s achievements have been widely acknowledged, including the prestigious AANS/CNS Elekta Tumor Section Award. With nearly 1,000 citations and an H-index of 16, his scientific impact is evident and growing. His work is frequently published in high-impact journals and has collectively amassed an impact factor exceeding 100. These accolades underscore the academic community’s trust in his research. Cheng’s dual patents, numerous publications, and ongoing contributions mark him as a leader in neurosurgical innovation. His recognition reflects not just individual brilliance but a sustained dedication to advancing global standards in neuro-oncology.

🌐 IMPACT AND INFLUENCE

YE CHENG’s influence extends beyond the laboratory, shaping both patient care and scientific discourse. His novel insights into glioma behavior guide clinical decision-making and inspire fellow researchers to reexamine tumor biology through the lens of brain evolution. Internationally, his work has contributed to evolving diagnostic protocols, especially in integrating advanced imaging into surgical planning. As a mentor and collaborator, Cheng empowers emerging scientists, amplifying his impact through knowledge transfer. His contributions resonate through academic, clinical, and technological communities, ensuring that his research continues to influence the next generation of neuroscientists.

🔮 LEGACY AND FUTURE CONTRIBUTIONS

YE CHENG’s legacy is grounded in his vision for integrative, personalized neurosurgery. He aims to further explore the intersection of brain development and tumor growth, refining diagnostic imaging and targeted therapies. Plans for AI-assisted imaging diagnostics and expanded global collaborations signal a dynamic future. Cheng’s continued efforts promise not only technological breakthroughs but also more compassionate and effective treatments. By shaping the field’s evolution through inquiry, invention, and mentorship, he’s laying the groundwork for a future where brain tumors are better understood—and more precisely treated—than ever before.

Notable Publication

Title: Systematic pan-cancer analysis identifies DNASE2 as a potential prognostic marker and immunotherapeutic target for glioblastoma multiforme
Authors: J. Cao, S. Chen, P. An, S. Li, Y. Cheng
Journal: Genes and Diseases, 2025

Title: Cortical Origin-Dependent Metabolic and Molecular Heterogeneity in Gliomas: Insights from 18F-FET PET
Authors: H. Diao, X. Wu, X. Li, J. Lu, J. Tang
Journal: Biomedicines, 2025

Title: Inferring the genetic relationships between unsupervised deep learning-derived imaging phenotypes and glioblastoma through multi-omics approaches
Authors: L. Ye, Y. Cheng, P. Li, Y. Wang, W. Ma
Journal: Briefings in Bioinformatics, 2025